Exact confidence interval estimation for the Youden index and its corresponding optimal cut-point
نویسندگان
چکیده
منابع مشابه
Generalized Confidence Intervals for Partial Youden Index and its Corresponding Optimal Cut-Off Point
In the field of diagnostic test studies, the accuracy of a diagnostic test is essential in evaluating the performance of the test. The receiver operating characteristic (ROC ) curve and the area under the curve (AUC ) are widely used in such evaluation procedures. Meanwhile, the Youden index is also introduced into practice to measure the accuracy of the diagnostic test from another aspect. The...
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Costs can hamper the evaluation of the effectiveness of new biomarkers. Analysis of smaller numbers of pooled specimens has been shown to be a useful cost-cutting technique. The Youden index (J), a function of sensitivity (q) and specificity (p), is a commonly used measure of overall diagnostic effectiveness. More importantly, J is the maximum vertical distance or difference between the ROC cur...
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The Youden Index is a frequently used summary measure of the ROC (Receiver Operating Characteristic) curve. It both, measures the effectiveness of a diagnostic marker and enables the selection of an optimal threshold value (cutoff point) for the marker. In this paper we compare several estimation procedures for the Youden Index and its associated cutoff point. These are based on (1) normal assu...
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The Youden Index is a summary measurement of the receiver operating characteristic (ROC) curve for the accuracy of a diagnostic test with ordinal or continuous endpoints. The bootstrap confidence interval based on the adjusted proportion estimate was shown to have satisfactory performance among the existing confidence intervals, including the parametric interval via the delta method. In this ar...
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The ROC (Receiver Operating Characteristics) curves are frequently used to measure the effectiveness of diagnostic biomarkers. A global measure of the ROC curve is the Youden index, the maximum difference between sensitivity and 1-specificity. The cut-point is the value for which the maximum is attained. In this paper we obtain the asymptotic distribution of the optimal cut-point under the assu...
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ژورنال
عنوان ژورنال: Computational Statistics & Data Analysis
سال: 2012
ISSN: 0167-9473
DOI: 10.1016/j.csda.2010.11.023